Champions Harlequins welcome Wasps to the Stoop for this Premiership encounter.
The two teams could not be entering this match with more contrasting fortunes. Harlequins are on a three-game losing run, while the visitors are on a four-game winning run.
Quins are currently in fourth place and are just hanging on to the last playoff spot. They are just one point ahead of their opponents in this match.
Wasps are steadily getting their injured players back and look a different team from the one that struggled earlier in the season when they were decimated by injuries.
Harlequins need to stop their slide in form or else run the risk of not making the playoffs. If Harlequins are defeated in this match, they will lose their fourth spot to Wasps.
How could Harlequins vs Wasps line up?
In a strange twist of fate, for the first time this season, Wasps are near full strength, while Quins have arguably their weakest team available.
The home team have been hurt with England call-ups and are missing key players Marcus Smith, Joe Marler, Alex Dombrandt, and Joe Marchant. These players formed the nucleus of the Quins title-winning team and are almost impossible to replace. They will need their replacements to step up in this match as this is quickly turning into a battle for the playoffs.
Wasps will be looking to players such as Paolo Odogwu and Alfie Barbeary to continue with their brilliant try-scoring form as both of them got on the scoresheet in their dramatic win over Exeter Chiefs a few weeks ago.
Quins will look to giant centre André Esterhuizen and his South African counterpart Tyrone Green to create some much-needed magic to end their win drought.
While the current league form may make Wasps a strong bet, Quins are at their most dangerous when they are the underdogs and could bounce back with a win in this match.